Grey’s Anatomy is in season 22 with more than 450 episodes on the board, and Shonda Rhimes says the finish line is no clearer now than it was years ago. On October 13, 2025, Rhimes appeared on NBC’s morning show with Craig Melvin and explained that longevity has scrambled her once-firm plan for the final chapter. “I’d say back around episode 150 I knew how it was gonna end,” she said. “Now we’re at 450—I have no idea.”

Rhimes emphasized that she never expected the ABC medical drama to last this long. “I wasn’t sure we’d get past season four or five. So the fact that we’re here in 22, season 22, is insane.” She added that the decision about when to close the book isn’t entirely hers anymore: “I feel like at this point, that decision is not mine as much as it is the fans,” and she wants “

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