Once you open a tube of caulk, it can start drying out pretty quickly. But with the proper sealing and storage, you could keep it fresh for up to two months.
How Long Does Caulk Last In The Tube After It Has Been Opened?

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Once you open a tube of caulk, it can start drying out pretty quickly. But with the proper sealing and storage, you could keep it fresh for up to two months.