The No. 13 Notre Dame Fighting Irish (4-2) are set to host the No. 20 USC Trojans (5-1) on Saturday in one of college football's most bitter rivalries. The Irish dropped their first two games of the season, but have won four straight since. Notre Dame notched a 36-7 blowout win over N.C. State in its last outing. The Trojans' lone loss came on the road against Illinois on Sept. 27. USC was dominant in its most recent game, blowing out Michigan 31-13 on Oct. 11. Notre Dame leads the all-time series 52-37-5. Both teams are 3-3 against the spread this season.

Kickoff from Notre Dame Stadium in South Bend is set for 7:30 p.m. ET. The Irish are 9.5-point favorites in the latest Notre Dame vs. USC odds, while the over/under for total points scored is 60.5. Before making any USC vs. Notre Dame p

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