Police divers hope to unearth the remains of an Indigenous teenager who vanished more than three decades ago, years after weighed-down clothes were found in a river.

Colleen Walker-Craig was 16 when she was last seen in Bowraville in the mid-north coast of NSW in September 1990.

Her four-year-old cousin, Evelyn Greenup, and Clinton Speedy-Duroux, 16, also went missing from the town in late 1990 but it took years before detectives suspected it could be the work of a serial killer.

Two of the Indigenous children's remains were found in nearby bushland in 1991, but Colleen's body has never been found.

The NSW Coroner concluded she had most likely been murdered.

Investigators on Friday said they were launching a two-day search operation for the 16-year-old's remains, homing in on two key

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