Alabama Crimson Tide quarterback Ty Simpson (15) receives the ball during the first quarter against the Tennessee Volunteers at Saban Field at Bryant-Denny Stadium in Tuscaloosa, Alabama.

The No. 4 Alabama Crimson Tide (6-1, 4-0 SEC) and the South Carolina Gamecocks (3-4, 1-4) meet Saturday at Williams-Brice Stadium in Columbia, South Carolina. Kickoff is scheduled for 3:30 p.m. ET (ABC). Let's analyze BetMGM Sportsbook's NCAA football odds around the Alabama vs. South Carolina odds and make our expert college football picks and predictions for the best bets.

Alabama leads the all-time series 12-4, including a 27-25 win in Tuscaloosa last season Oct. 12, 2024. South Carolina easily covered as a 21-point underdog as the Over (50) cashed.

The Crimson Tide routed Tennessee 37-20 last Saturday as a 9.5-point favorite as the Under (61) cashed. QB Ty Simpson threw for 253 yards and 2 TDs in the victory. Alabama has won 6 in a row since a 31-17 opening-game loss at Florida State. The Tide are 5-0-1 against the spread (ATS) in the 6-game span, too, while the Under has cashed in each of the past 4 outings.

The Gamecocks were tripped up 26-7 at home against Oklahoma last week, failing to cover as a 4.5-point underdog with the Under (43) cashing. South Carolina QB LaNorris Sellers completed 17 of 25 passes for 124 yards, 1 TD and 0 INT. The Gamecocks have dropped 4 of their past 5 games and are 2-4 ATS in their past 6. The Under has hit in the past 2 games and 5 of 7 outings this season.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

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Alabama at South Carolina odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 9:40 a.m. ET.

  • Moneyline (ML): Alabama -450 (bet $450 to win $100) | South Carolina +350 (bet $100 to win $350)
  • Against the spread: Alabama -11.5 (-105) | South Carolina +11.5 (-115)
  • Over/Under (O/U): 47.5 (O: -110 | U: -110)

Alabama at South Carolina picks and predictions

Prediction

Alabama 30, South Carolina 12

Moneyline

Alabama (-450) will cost you 4½ times your potential return, and that's way too much for a straight bet. While it's not recommended to include such heavy favorites in a parlay, it isn't too bad if you toss Bama in with at least 7 or 8 teams.

PASS as a straight up wager, even with boosts or promos.

Against the spread

ALABAMA -11.5 (-105) is a strong play on the road against skidding South Carolina.

The Crimson Tide have looked like one of the best teams in the country in the past 6 weeks, bouncing back nicely from that stunning loss in Tallahassee. Bama is 5-0-1 ATS in the past 6 games and 4-0 ATS in the past 4 tries as a favorite of 9.5 points or higher.

The Gamecocks covered as a double-digit underdog at Mizzou Sept. 20, but they're just 2-4 ATS in the past 6 games.

Over/Under

UNDER 47.5 (-110) is worth a look in this SEC battle in COLA.

The Under has cashed in each of South Carolina’s past 2 games, as the Gamecocks have averaged just 8.5 points per game (PPG) while allowing only 23 PPG during that span. Carolina has also held opponents to 20 points or fewer in 4 of 7 games this season, so the defense hasn’t been that bad.

Alabama has also hit the Under in 4 straight games, with its defense allowing 24 points or fewer in 6 consecutive contests. Be careful, though -- Bama has surrendered 21 or more points in all 3 of its road games, averaging 25.3 PPG allowed away from home.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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This article originally appeared on Sportsbook Wire: Alabama Crimson Tide at South Carolina Gamecocks odds, picks and predictions

Reporting by Daniel Dobish, Sportsbook Wire / Sportsbook Wire

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