Given the fact that the San Francisco 49ers live on the west coast and reside in a different conference, it's not all that surprising that the Texans have only faced the 49ers five times in franchise history. Unfortunately, the Texans have only won once (2009) and only scored 67 points in those five games against the 49ers. That win DID take place at NRG Stadium where the Texans and the 49ers will clash on Sunday afternoon.

The 2025 version of the 49ers is a gritty bunch that has handled as much injury adversity as any team I can remember. They lost All-Pro LB Fred Warner for the season on the same night that they finally got All-Pro TE George Kittle back. They lost All-Pro DE Nick Bosa a few weeks ago to a knee injury and he's out for the entire season. They have key starters that have m

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