Oral TXA as effective and safe as IV TXA in hip and knee arthroplasty: study

Oral TXA is as effective and safe as IV TXA in patients undergoing hip and knee arthroplasty: study

Tranexamic acid (TXA) has been extensively used in total hip and total knee arthroplasty (THA and TKA) to reduce blood loss. The commonly investigated routes of TXA administration include oral, intravenous, intra-articular, and topical methods. However, the ideal route of administration remains controversial. Feng et al conducted a study to evaluate and compare the efficacy and safety of oral versus intravenous tranexamic acid in primary total knee and hip arthroplasty.

The PubMed, Web of Science, Cochrane Library and Embase databases were systematically searched for relevant randomized controlled trials (RCTs). Decline of hemoglobin (DHB), total blood loss (TBL), length of hospital stay