Louisville ran for a season-high 317 yards and the No. 19 Cardinals used their big-play capabilities to hold off upset-minded Boston College 38-24 at home on Saturday.

Isaac Brown needed just 14 carries to amass a career-high 205 yards, and Keyjuan Brown added 95 on 10 rushes. Both scored on big plays and also set up Miller Moss' two scoring runs for Louisville (6-1, 3-1 Atlantic Coast Conference).

Moss threw for 187 yards on 15-of-27 passing with an interception and a touchdown. His second run gave Louisville the lead for good, 14-10, with 1:42 left in the first half.

Isaac Brown, who ran for 151 yards on five carries in the first half, added a 62-yard touchdown 40 seconds later to make it an 11-point game. However, the Eagles (1-7, 0-5) refused to go away, and Brown's fumble to start

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