The Buffalo Bills are fresh off a bye week and are looking to get back on track after dropping each of their last two games, and they face a hot Carolina Panthers team that's won three in a row and is a perfect 3-0 at home this year. The Carolina offense has done well of late, but the team faces a Bills side with reigning MVP Josh Allen that's surely angry after falling to 4-2 after a perfect 4-0 start.

Kickoff from Bank of America Stadium is set for 1 p.m. ET, and the Bills are 7.5-point favorites, according to the latest Bills vs. Panthers odds. The over/under for total points scored is 48.5. The Bills are -398 money line favorites (risk $398 to win $100), while the Panthers are +310 underdogs. Before you make any Panthers vs. Bills picks, make sure to check out what the SportsLine Proj

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