Talking Heads frontman, Broadway innovator and all-around creative polymath David Byrne is once again blurring the line between art and science, this time in the middle of downtown Chicago. Opening in March 2026 inside the historic Reid Murdoch Building at 333 N. LaSalle Street, is Byrne’s latest experiment in perception, identity and theatrical immersion—and yes, it’s happening inside a real office space.

Created with writer and philanthropist Mala Gaonkar, the 15,000-square-foot experience invites audiences of just 16 at a time to explore a series of rooms designed to mess with your senses and make you question, well, yourself.

“You experience the unreliability of your senses, and therefore your own memories and identity,” Byrne told WBEZ . “By the end of the show, yo

See Full Page