The No. 17 Louisville Cardinals (6-1, 3-1 ACC) and Virginia Tech Hokies (3-5, 2-2) meet in an ACC showdown Saturday afternoon. Kickoff from Lane Stadium in Blacksburg, Virginia, is set for 3 p.m. ET (The CW Network). Let's analyze BetMGM Sportsbook's NCAA football odds around the Louisville vs. Virginia Tech odds and make our expert college football picks and predictions for the best bets.

The Cardinals beat the Boston College Eagles 38-24 Saturday, failing to cover as a 26-point home favorite as the Over (54) cashed. The game prior, a 24-21 road win over No. 9 Miami Hurricanes, was Louisville's staple victory of the season. Its lone loss came at home in overtime to the Virginia Cavaliers in Week 6. Through 7 games, the Cardinals are 2-5 against the spread (ATS) and 4-3

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