Joey Pollizze analyzes all 2025 fantasy football Week 10 defenses (DEF) -- streamers, sits/starts, and D/ST waiver wire pickups to add. His Week 10 rankings and tiers for all of the NFL defenses.

Welcome, RotoBallers, to our fantasy football defense streamers, starts, and tiered rankings for Week 10 of the 2025 season! This article will be your go-to stop for all defensive rankings and streamers for the entire season.

We will break down defenses into separate tiers in this article below. Fantasy managers should be starting one of the seven defenses listed in Tier 1. If all seven of those D/ST are taken, pivot to starting a defense in either Tier 2 or Tier 3. In most cases, Tier 4, Tier 5, and Tier 6 defenses should be avoided.

So, let's look at the best fantasy defenses for Week 10.

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