A cargo plane has crashed on takeoff from the main airport in Louisville, Kentucky, with video showing widespread fire consuming buildings near the airport and smoke billowing into the sky.

The flight, UPS2976, was a wide-body McDonnell Douglas MD-11aircraft bound for Honolulu, Hawaii, according to FlightRadar24 records. Louisville airport is a major hub for UPS.

The US Federal Aviation Administration confirmed the crash occurred on takeoff about 5.15pm on Tuesday (9.15am AEDT) and would be investigated by the National Transportation Safety Bureau.

The Louisville Metro Police Department said it was responding to the crash along with multiple other agencies, and that injuries had been reported. The crash occurred near Fern Valley and Grade Lane, it said.

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