San Antonio Spurs at Los Angeles Lakers odds, picks and predictions

Los Angeles Lakers guard Luka Doncic (77) passes the ball against the Miami Heat during the second half at Crypto.com Arena in Los Angeles, California.

The Los Angeles Lakers (6-2) host the San Antonio Spurs (5-1) Wednesday night at Crypto.com Arena in Los Angeles, California. Tip is scheduled for 10 p.m. ET (ESPN). Let's analyze BetMGM Sportsbook's NBA odds around the Spurs vs. Lakers odds and make our expert NBA picks and predictions for the best bets.

2024-25 season series: Lakers won 3-1

San Antonio dropped its first game of the season on Sunday, snapping a 5-game winning streak, with a 130-118 loss to the Phoenix Suns while failing to cover as a 5-point road favorite with the Over (227.5) hitting. G Stephon Castle scored a team-high 26 points with 7 rebounds and 5 assists, while F Victor Wembanyama was held to just 9 points and 9 rebounds. The Spurs trailed by as many as 31 points in the defeat.

Los Angeles has won each of its last 4 games after handling the Portland Trail Blazers 123-115 on Monday while covering as a 9.5-point road underdog with the Over (228) hitting. C Deandre Ayton scored a team-high 29 points with 10 rebounds, while F Rui Hachimura added 28, and G Nick Smith Jr. added 25. The Lakers trailed by as many as 13 points in the upset victory.

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Spurs at Lakers odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 11:23 a.m. ET.

Moneyline (ML): Spurs +115 (bet $100 to win $115) | Lakers -140 (bet $140 to win $100)
Against the spread (ATS): Spurs +2.5 (-110) | Lakers -2.5 (-110)
Over/Under (O/U): 227.5 (O: -115 | U: -105)

Spurs at Lakers key injuries

Spurs

G De'Aaron Fox (hamstring) out
G Dylan Harper (calf) out
C Luke Kornet (ankle) out
F Kelly Olynyk (heel) questionable
F Jeremy Sochan (wrist) questionable
F Lindy Waters III (eye) questionable

Lakers

C Jaxson Hayes (ankle) probable
F LeBron James (sciatica) out
F Maxi Kleber (abdominal), out
G Austin Reaves (groin) questionable
F Adou Thiero (knee) out
G Gabe Vincent (ankle) out

For most recent updates: Official NBA injury report.

Spurs at Lakers picks and predictions

Prediction

Lakers 119, Spurs 117

Moneyline

BET LAKERS (-140).

The Lakers have been hot of late, winning 4 games in a row despite being plagued by injuries. They will see G Luka Doncic return, who is averaging 41.3 points, 11.5 rebounds, and 8.3 assists per game this season, a massive production boost. While G Austin Reaves, who is averaging 31.1 PPG, is uncertain, Doncic's return will make a huge difference.

For the Spurs, expect Wembanyama to return to his normal production, but the team showed just how reliant they were on the 7-footer in Sunday's loss. Without G Dylan Harper, who is averaging 14 PPG, and C Luke Kornet, who is averaging 8 rebounds per game, the Spurs will lose too much production in this matchup to come out on top.

Against the spread

PASS.

In a game that features Doncic on one side and Wembanyama on the other, with either player capable of taking control of the game and keeping it close, the moneyline has the best value.

Over/Under

BET OVER 227.5 (-115).

The Spurs have scored at least 118 points in all but one game this season, including 120 in 3 of their 6 games, and are averaging 118.2 PPG.

The Lakers have scored at least 123 points in back-to-back games and at least 116 in 6 of their 8 games. They are averaging 119.8 PPG. They have allowed at least 112 points in each of their last 6 games.

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This article originally appeared on Sportsbook Wire: San Antonio Spurs at Los Angeles Lakers odds, picks and predictions

Reporting by Seth Orlemann, Sportsbook Wire / Sportsbook Wire

USA TODAY Network via Reuters Connect