The Los Angeles Lakers (6-2) host the San Antonio Spurs (5-1) Wednesday night at Crypto.com Arena in Los Angeles, California. Tip is scheduled for 10 p.m. ET (ESPN). Let's analyze BetMGM Sportsbook's NBA odds around the Spurs vs. Lakers odds and make our expert NBA picks and predictions for the best bets.

2024-25 season series: Lakers won 3-1

San Antonio dropped its first game of the season on Sunday, snapping a 5-game winning streak, with a 130-118 loss to the Phoenix Suns while failing to cover as a 5-point road favorite with the Over (227.5) hitting. G Stephon Castle scored a team-high 26 points with 7 rebounds and 5 assists, while F Victor Wembanyama was held to just 9 points and 9 rebounds. The Spurs trailed by as many as 31 points in the defeat.

Los Angeles has

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