Is Brandon Aiyuk out for the season? When is Brandon Aiyuk coming back? The latest Brandon Aiyuk injury update and fantasy football outlook heading into Week 10 of 2025.

San Francisco 49ers wide receiver Brandon Aiyuk (knee) still hasn't played a single snap of football in 2025 after suffering a devastating knee injury in Week 7 of 2024. His leg was struck by a defender while it was planted in the ground, causing his knee to buckle.

The former Arizona State Sun Devil was a top-10 fantasy wide receiver in PPR leagues in 2023, so it was a huge blow to fantasy teams that drafted him last year when he was declared out for the season with a torn ACL and MCL.

We're now nine weeks into the 2025 NFL season, and Aiyuk has had over a year to recover to this point. But will he be able to come ba

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