College football picks for Week 11, including Texas Tech

Oct 18, 2025; Provo, Utah, USA; BYU Cougars quarterback Bear Bachmeier (47) drops back to pass against the Utah Utes during the first quarter at LaVell Edwards Stadium. Mandatory Credit: Rob Gray-Imagn Images

Week 10 may not have brought the blockbuster upsets of highly ranked teams, but there were certainly quite a few results that shook up the College Football Playoff picture on the first weekend of November.

We'll hope Week 11 can provide the same, and the headlining matchup is what could be a pivotal Big 12 contest between unbeaten BYU and one-loss Texas Tech in Lubbock, with the winner likely to emerge as the favorite to earn the league's autobid — though it may not be the only matchup between the two teams this year.

In the SEC, we have a ranked matchup between Texas A&M and Missouri with the latter looking to keep its slim playoff hopes alive. Meanwhile, in the Big 10, Oregon looks to remain in strong playoff positioning as it hits the road to take on an Iowa team that is a tough out on the road.

Our experts are back to give you their picks for all the top games on the Week 11 slate.

Tulane at Memphis (Friday night)

Opening Line: Memphis -4.5

Schuster: Tulane +4.5

AAC Chaos may be the new ACC Chaos, but Tulane should win this one outright.

D'Andrea: Memphis -4.5

I don't doubt the Tigers' ability to disappoint or the AC's ability to generate chaos. But Jake Retzlaff, buddy, last week was... Ooof.

Martinelli: Memphis -4.5

The Tigers are in control of their own CFP destiny, and if they're going to drop a second game this season, it won't be against Tulane. Especially rolling with one of the best defenses in the American.

Nettuno: Memphis -4.5

It's just too hard for me to trust Tulane after what they did against UTSA.

Grimes: Tulane +4.5

These teams are close enough. Take the points.

Indiana at Penn State

Opening Line: Indiana -16.5

Schuster: Indiana -14.5

Once again, the Hoosiers will cover this line before halftime.

D'Andrea: Indiana -14.5

I don't know how big the point spread would have to be to get me to bet against the Hoosiers vs. an unranked team. But, my god, try explaining this line to someone in 2023.

Martinelli: Indiana -14.5

It's not nice to kick people when they're down, but the Hoosiers are going to roll into Happy Valley and do just that.

Nettuno: Indiana -14.5

I may never pick an underdog to cover against Indiana again.

Grimes: Indiana -14.5

I’d blindly take the Indiana spread in this one.

Georgia at Mississippi State

Opening Line: Georgia -9.5

Schuster: Georgia -8.5

Here's the thing about the cowbells: They are very annoying, but become background noise pretty quickly. Dawgs roll here.

D'Andrea: Mississippi State +8.5

UGA's been a bit underwhelming and Starkville is a charming* place to play (*terrible)

Martinelli: Mississippi State +8.5

This feels like a dangerous pick, but with the way Georgia has been playing, I don't know if it can win by more than a touchdown on the road.

Nettuno: Georgia -8.5

Mississippi State has been a tough out, but I'm not sure they can slow down Georgia's offense.

Grimes: Mississippi St +8.5

Despite a 1-2 record in its last three games, Mississippi State’s scoring margin is just minus-6 in that span.

BYU at Texas Tech

Opening Line: Texas Tech -9.5

Schuster: Texas Tech -10

OK, I'm back to believing the Red Raiders are the best team in the Big 12. Tune in next week when another best team emerges!

D'Andrea: BYU +10

The Cougars just keep showing up as underdogs. Doubting them always seems to work out poorly.

Martinelli: BYU +10

I'm going with Bear Bachmeier and the Cougars until they give me a reason not to — but this Texas Tech game might end up being that reason.

Nettuno: BYU +10

I like Texas Tech to win, but this is just way too many points.

Grimes: BYU +10

I do expect the Red Raiders to win. I don’t expect it to be by double-digits.

Texas A&M at Missouri

Opening Line: Texas A&M -5.5

Schuster: Texas A&M -7

It's Fraud O'Clock in CoMo and the Aggies are primed to take advantage.

D'Andrea: Mizzou +7

The Tigers are coming off a bye, at home and generally pretty good at keeping things close.

Martinelli: Missouri +7

I've got plenty of faith in Marcel Reed and the undefeated Aggies here, but not enough to blow out Mizzou on the road.

Nettuno: Texas A&M -7

I don't trust Mizzou with a backup quarterback here, even at home.

Grimes: Texas A&M -7

I'm not sure Missouri has enough offensive firepower to make the Aggies sweat.

Oregon at Iowa

Opening Line: Oregon -6.5

Schuster: Oregon -6

This is OBVIOUSLY a trap, I tell myself while walking right into it.

D'Andrea: Iowa +6

It's looking like a gross day at Kinnick Stadium, where weird, sloppy football is the Iowa way.

Martinelli: Oregon -6

Begging the Ducks (and Hawkeyes) to not make me regret this.

Nettuno: Oregon -6

Man, this is tricky for Oregon. I'll give the Ducks the benefit of the doubt, but I don't feel great about it.

Grimes: Oregon -6

In what could be a very ugly game.

Wake Forest at Virginia

Opening Line: Virginia -8.5

Schuster: Virginia -6.5

This would be the game the Cavaliers expose themselves after getting included in the CFP bracket, but I can't fade the Hoos at home.

D'Andrea: Virginia -6.5

Who am I to doubt the Cavaliers?

Martinelli: Virginia -6.5

If the line hadn't shifted, I would go the other way. But the Cavaliers should be able to win by a touchdown.

Nettuno: Virginia -6.5

Virginia has a habit of playing down to its opponent, but after the way Wake lost to FSU, I think the Cavaliers will be fine here.

Grimes: Virginia -6.5

Give me the home team. Virginia beat the same FSU team that just destroyed Wake by 35 points.

Cal at Louisville

Opening Line: Louisville -18.5

Schuster: Cal +20.5

Way way way too many points.

D'Andrea: Cal +20.5

That's a lot of points against an inscrutable Golden Bears team.

Martinelli: Cal +20.5

I don't care that the Bears' offense is one of the worst in the ACC, but phew, that's way too many points.

Nettuno: Cal +20.5

Cal isn't that good, but this spread is stunningly large.

Grimes: Cal +20.5

Louisville hasn’t won a game by this many points since its third game of the season.

LSU at Alabama

Opening Line: Alabama -6.5

Schuster: LSU +10

The Tigers are going to win outright purely out of spite for Brian Kelly.

D'Andrea: Alabama -10

Bama has won each of its home games by at least 16 points.

Martinelli: LSU +10

Alabama is winning, but LSU finally being free of Brian Kelly might energize the Tigers.

Nettuno: LSU +10

An interim bump will *probably* be enough for the Tigers to keep this one fairly close.

Grimes: LSU +10

Maybe firing Brian Kelly will give the Tigers a little boost.

Navy at Notre Dame

Opening Line: Notre Dame -24.5

Schuster: Navy +26.5

Put some respect on Blake Horvath's name!

D'Andrea: Navy +26.5

You'll never catch me laying nearly four touchdowns against Blake Horvath.

Martinelli: Navy +26.5

Too many points when this Navy team, behind Blake Horvath, is more dangerous than it usually is. The Fighting Irish will win, but maybe by two or three touchdowns.

Nettuno: Notre Dame -26.5

I've seen what Marcus Freeman's defense does against service academies. Next.

Grimes: Notre Dame -26.5

The Irish won this game by 37 last year.

This article originally appeared on For The Win: College football picks for Week 11, including Texas Tech-BYU

Reporting by Tyler Nettuno, For The Win / For The Win

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