Saquon Barkley had the most productive game of his NFL career during Week 12 of the 2024 NFL season. The Philadelphia Eagles running back had a career-high 255 rushing yards on 26 carries and added 47 receiving yards on four catches in a 37-20 win against the Los Angeles Rams in Inglewood, California.

Barkley opened the second half with a 70-yard run for a score and then sealed the victory with a 72-yard rushing touchdown with 2:44 to play. Barkley's 255 yards on the ground were the ninth-most in a single game in NFL history.

In November 2025, Indianapolis Colts running back Jonathan Taylor ran for 244 yards vs. the Atlanta Falcons , setting the franchise touchdown record and scoring a walk-off touchdown in overtime that allowed the Colts to pull off a 31-25 win .Though Tayl

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