Week 10 of the 2025 fantasy football season featured huge days by a mix of every position, but also several disappointing efforts by some of the league's best options.

Who were the big winners and losers?

Matt Bowen and Tristan H. Cockcroft offer their analyses.

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Ranking winners | Ranking losers

Biggest injuries and what's next

Ranking fantasy winners of Week 10

1. Jonathan Taylor , RB, Indianapolis Colts : In his highlight game -- thus far -- of a massive season, Taylor scored 49.6 fantasy points, the most by any player this season and tied for 36th on the all-time single-game list among running backs. Yes, it came in an overtime game, and yes, he had a massive amount of volume (32 carries and 35 total touches), but Taylor's 83-yard rushing score in the fourt

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