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Mayo Clinic researchers created a model to predict Alzheimer’s-related cognitive decline.

The tool uses amyloid PET scans and genetic information and predicts both the lifetime and 10-year risks of developing mild cognitive impairment (MCI) and dementia.

Not only does the tool predict risk, but it can also predict it before symptoms appear.

As people age, their risk of cognitive decline rises. In 2025, about 7 million Americans aged 65 and older have Alzheimer’s disease , and this number is expected to grow .

Mayo Clinic researchers noted that Alzheimer’s begins long before symptoms appear, but said the link between biomarkers and future risk was unclear.

Using 20 years of data, they developed a tool that predicts 10-year and lifetime risk of cognitive impa

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