Via Coley Cleary, USA TODAY SMG

Week 12 of the 2025 college football season continues with a Saturday afternoon game at Wrigley Field between the Michigan Wolverines and Northwestern Wildcats.

The Wolverines come into Saturday on a three-game winning streak and it has pushed their record to 7-2 overall and 5-1 in the Big Ten.

The Wildcats are going the opposite direction as they have lost two in a row and it has dropped them to 5-4 overall and 3-3 in the Big Ten.

Stream Northwestern vs. Michigan

If you're looking to get back in the swing of football season and need some betting advice for Saturday's matchup in Chicago, we've got you covered. Here are the latest odds for the game, courtesy of BetMGM.

Northwestern vs Michigan game odds:

All college football odds via BetMGM

  • Spread: Michigan -11.5 (-105), Northwestern +11.5 (-115)
  • Money Line: Michigan -475, Northwestern +350
  • Over-Under: Over 41.5 (-110), Under 41.5 (-110)

Northwestern vs Michigan prediction, pick:

The Wolverines are playing solid football, but the offense still hasn't found its stride. They are doing enough to win games, but they aren't blowing teams out. The Wildcats are a pesky team and are capable of slowing down the Wolverines' offense. This game is going to be closer than expected, but the Wolverines do pull out the win.

Prediction: Michigan 24, Northwestern 20

Best Bet: Northwestern +11.5, Over 41.5

Northwestern vs Michigan channel, start time, streaming:

Time: 12 p.m. ET

TV Channel: FOX

Live Stream: FOX App

Get more betting analysis and predictions at Sportsbook Wire.

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This article originally appeared on College Sports Wire: Northwestern vs Michigan: Week 12 College Football Betting Odds, Prediction, Pick

Reporting by Adam Childs, College Sports Wire / College Sports Wire

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