An individual patient-level meta-analysis assessed and compared the performance of urinary albumin–creatinine ratio (UACR) and urinary protein–creatinine ratio (UPCR) across chronic kidney disease (CKD)-related clinical outcomes. The analysis found that UACR was more strongly associated with development of kidney failure than UPCR, supporting the use of UACR as the preferred measure to stratify patients at risk for CKD-related outcomes. The findings are published in Annals of Internal Medicine.

Researchers from the Chronic Kidney Disease Prognosis Consortium (CKD-PC) studied data from 148,994 participants in cohorts of the CKD-PC who had UACR and UPCR measured on the same day. Cohorts are eligible to join the CKD-PC if they have sufficient data on kidney function and subsequent clini

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