Metformin May Blunt Benefits of Exercise, Suggests Study

USA: A placebo-controlled study published in The Journal of Clinical Endocrinology & Metabolism found that the diabetes drug metformin may reduce the positive effects of exercise , such as improvements in blood pressure , physical fitness, and blood glucose control . The research, led by Steven K. Malin from Rutgers University and colleagues, examined whether metformin interferes with vascular benefits typically achieved through exercise training in adults at risk for metabolic syndrome. Although the drug is widely used as first-line therapy to manage elevated blood sugar and lower cardiovascular risk, earlier research has hinted that it may counteract certain exercise-induced metabolic improvements. Until now, however, its impact on exercise-related vascular insulin sensitivit