Retatrutide: What We Know About Side Effects — Including Why Some Users Report Anxiety

(LOOTPRESS) – Retatrutide is one of the most anticipated drugs in modern metabolic medicine. As a “triple agonist” targeting GLP-1, GIP, and glucagon receptors, it has shown remarkable potential in clinical trials for weight loss, improved insulin sensitivity, and metabolic health—some calling it the next major leap forward beyond semaglutide and tirzepatide.

But as with any powerful metabolic therapy, the benefits come with a side-effect profile that users need to understand. While gastrointestinal effects are well-documented, a growing number of patients and clinicians have begun discussing anxiety—a side effect less talked about but increasingly relevant as these therapies expand.

What Is Retatrutide?

Retatrutide (formerly LY3437943) is a once-weekly injectable drug developed by Eli