Thanksgiving marks the start of the home stretch of the NFL season, which means we’re only a week away from the start of the proverbial Witching Hour, as Scott Hansen would call it. And this slate starts strong, with a Buffalo Bills vs. Houston Texans matchup to kick things off. Ahead of that, here is the ClutchPoints 2025 NFL Week 12 picks, predictions, and odds column.

On paper, Week 12 could be a bit of a snoozefest. There are three games with double-digit spreads on the calendar and only two with lines that are less than a field goal. Plus, we’ll have quarterback luminaries like Tyrod Taylor, Marcus Mariota, Davis Mills, Jameis Winston, Jacoby Brissett, Shedeur Sanders, and likely Mason Rudolph starting.

Still, there are some solid division games ( Minnesota Vikings vs. Green Bay

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