Nov 14, 2025; Eugene, Oregon, USA; Oregon Ducks quarterback Dante Moore (5) throws a pass for a first down during the first half against the Minnesota Golden Gophers at Autzen Stadium. Mandatory Credit: Troy Wayrynen-Imagn Images

Twenty-one of the top 25 teams in the Week 13 US LBM Coaches Poll will be in action on Saturday, Nov. 21.

Of those, nine are in the current College Football Playoff field. However, even with a jam-packed schedule, the action figures to be lighter this week, with many of the top teams playing a "cupcake" game ahead of rivalry week next weekend.

That does not mean Week 13 will lack big games. No. 5 Oregon (9-1, 6-1 Big Ten) vs. No. 16 USC (8-2, 6-1) could have ramifications on the Big Ten standings, while No. 8 Oklahoma vs. No. 21 Missouri could also have CFP ramifications.

Here is a look at picks, predictions and odds for all of Saturday's Week 13 games on the 2025 college football schedule:

Week 13 college football schedule

Odds courtesy of BetMGM as of Friday, Nov. 21

No. 1 Ohio State vs Rutgers

  • Date: Saturday, Nov. 22
  • Time: Noon ET
  • Location: Ohio Stadium (Columbus, Ohio)
  • Spread: Ohio State (-32.5)

Prediction: Ohio State 45, Rutgers 10

No. 3 Texas A&M vs Samford

  • Date: Saturday, Nov. 22
  • Time: Noon ET
  • Location: Kyle Field (College Station, Texas)
  • Spread: N/A

Prediction: Texas A&M 56, Samford 6

No. 4 Georgia vs Charlotte

  • Date: Saturday, Nov. 22
  • Time: 12:45 p.m. ET
  • Location: Samford Stadium (Athens, Georgia)
  • Spread: Georgia (-43.5)

Prediction: Georgia 49, Charlotte 3

No. 5 Oregon vs No. 16 USC

  • Date: Saturday, Nov. 22
  • Time: 3:30 p.m. ET
  • Location: Autzen Stadium (Eugene, Oregon)
  • Spread: Oregon (-10)

Prediction: Oregon 28, USC 20

No. 8 Oklahoma vs No. 21 Missouri

  • Date: Saturday, Nov. 22
  • Time: Noon ET
  • Location: Memorial Stadium (Norman, Oklahoma)
  • Spread: Oklahoma (-7)

Prediction: Oklahoma 24, Missouri 17

No. 9 Notre Dame vs Syracuse

  • Date: Saturday, Nov. 22
  • Time: 3:30 p.m. ET
  • Location: Notre Dame Stadium (Notre Dame, Indiana)
  • Spread: Notre Dame (-35.5)

Prediction: Notre Dame 38, Syracuse 3

No. 10 Alabama vs Eastern Illinois

  • Date: Saturday, Nov. 22
  • Time: 2 p.m. ET
  • Location: Bryant-Denny Stadium (Tuscaloosa, Alabama)
  • Spread: N/A

Prediction: Alabama 56, Eastern Illinois 14

No. 11 BYU vs Cincinnati

  • Date: Saturday, Nov. 22
  • Time: 8 p.m. ET
  • Location: Nippert Stadium (Cincinnati, Ohio)
  • Spread: BYU (-2.5)

Prediction: Cincinnati 30, BYU 24

No. 12 Georgia Tech vs Pittsburgh

  • Date: Saturday, Nov. 22
  • Time: 7 p.m. ET
  • Location: Bobby Dodd Stadium (Atlanta)
  • Spread: Georgia Tech (-2.5)

Prediction: Pitt 31, Georgia Tech 27

No. 13 Vanderbilt vs Kentucky

  • Date: Saturday, Nov. 22
  • Time: 3:30 p.m. ET
  • Location: FirstBank Stadium (Nashville)
  • Spread: Vanderbilt (-8.5)

Prediction: Vanderbilt 38, Kentucky 16

No. 14 Utah vs Kansas State

  • Date: Saturday, Nov. 22
  • Time: 4 p.m. ET
  • Location: Rice-Eccles Stadium (Salt Lake City)
  • Spread: Utah (-17.5)

Prediction: Utah 34, Kansas State 16

No. 15 Miami vs Virginia Tech

  • Date: Saturday, Nov. 22
  • Time: Noon ET
  • Location: Lane Stadium (Blacksburg, Virginia)
  • Spread: Miami (-18.5)

Prediction: Miami 28, Virginia Tech 20

No. 17 Michigan vs Maryland

  • Date: Saturday, Nov. 22
  • Time: 4 p.m. ET
  • Location: SECU Stadium (College Park, Maryland)
  • Spread: Michigan (-14)

Prediction: Michigan 30, Maryland 16

No. 18 Texas vs Arkansas

  • Date: Saturday, Nov. 22
  • Time: 3:30 p.m. ET
  • Location: DKR-Texas Memorial Stadium (Austin, Texas)
  • Spread: Texas (-9)

Prediction: Texas 34, Arkansas 14

No. 20 Tennessee vs Florida

  • Date: Saturday, Nov. 22
  • Time: 7:30 p.m. ET
  • Location: Ben Hill Griffin Stadium (Gainesville, Florida)
  • Spread: Tennessee (-4.5)

Prediction: Florida 38, Tennessee 30

No. 22 James Madison vs Washington State

  • Date: Saturday, Nov. 22
  • Time: 1 p.m. ET
  • Location: Bridgeforth Stadium (Harrisonburg, Virginia)
  • Spread: James Madison (-13.5)

Prediction: James Madison 28, Washington State 16

No. 23 North Texas vs Rice

  • Date: Saturday, Nov. 22
  • Time: 7:30 p.m. ET
  • Location: Rice Stadium (Houston)
  • Spread: North Texas (-17.5)

Prediction: North Texas 41, Rice 17

No. 24 Houston vs TCU

  • Date: Saturday, Nov. 22
  • Time: 4 p.m. ET
  • Location: TDECU Stadium (Houston)
  • Spread: Houston (-1.5)

Prediction: TCU 28, Houston 24

No. 25 Tulane vs Temple

  • Date: Saturday, Nov. 22
  • Time: 3:45 p.m. ET
  • Location: Lincoln Financial Field (Philadelphia)
  • Spread: Tulane (-9.5)

Prediction: Tulane 38, Temple 17

This article originally appeared on USA TODAY: College football Week 13 predictions, picks, odds for today's Top 25 games

Reporting by Ehsan Kassim, USA TODAY NETWORK / USA TODAY

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