Oklahoma quarterback John Mateer (10) points toward the Oklahoma section after a fourth quarter touchdown during a college football game between Tennessee and Oklahoma in Neyland Stadium in Knoxville, Tennessee.

The No. 21 Missouri Tigers (7-3, 3-3 SEC) and No. 8 Oklahoma Sooners (8-2, 4-2) meet Saturday at Memorial Stadium in Norman, Oklahoma. Kickoff is scheduled for noon ET (ABC). Let's analyze BetMGM Sportsbook's NCAA football odds around the Missouri vs. Oklahoma odds and make our expert college football picks and predictions for the best bets.

Oklahoma leads the all-time series 67-25-5, although Mizzou won the most recent meeting 30-23 Nov. 9, 2024, in Columbia, the first matchup as fellow SEC members. The two institutions hadn't met on the gridiron since September 2011, when both teams were part of the Big 12.

Mizzou picked up a 49-27 win over Mississippi State last time out as a 7-point favorite as the Over (50) cashed. QB Matt Zollers threw for 112 yards, 2 TDs and 1 INT. RB Ahmad Hardy went off, rumbling for 300 rushing yards and 3 TDs against the Bulldogs.

Since posting a 5-0 straight-up (SU) record to start the season, the Tigers are 2-3 SU in the past 5 outings, while going just 2-4-1 against the spread (ATS) in the previous 7 games. The Over has hit in the past 2 games to follow up a 4-game Under run.

Oklahoma picked up a 23-21 win at Alabama last Saturday as a 6.5-point underdog, taking full advantage of a bye and 2 weeks of preparation. QB John Mateer threw for 138 yards while running 10 times for 23 yards and a score. DB Eli Bowen had an 87-yard interception return for a touchdown to set the tone in the first quarter, en route to the Thorpe Award National Defensive Back of the Week honors.

The Sooners have rebounded from losses to Texas (23-6 as a 3-point underdog) Oct. 11 and to Ole Miss (34-26 as a 5.5-point favorite) Oct. 25. Oklahoma has not only saved its season with back-to-back road wins at Tennessee and Alabama, but its playoff chances are back on track.

– Rankings: US LBM Coaches Poll, conducted by the American Football Coaches Association and USA TODAY Sports

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Missouri at Oklahoma odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 7:45 a.m. ET.

  • Moneyline (ML): Missouri +200 (bet $100 to win $200) | Oklahoma -250 (bet $250 to win $100)
  • Against the spread: Missouri +5.5 (-105) | Oklahoma -5.5 (-115)
  • Over/Under (O/U): 42.5 (O: -115 | U: -105)

Missouri at Oklahoma picks and predictions

Prediction

Oklahoma 27, Missouri 20

Moneyline

Oklahoma (-250) will cost you 2½ times your potential return, and that's way too much risk for not enough reward for a standalone bet. As part of a multi-leg parlay, particularly of at least 4 or 5 legs, it would be OK to toss the Sooners into your ticket.

However, AVOID playing OU as a standalone play.

Against the spread

OKLAHOMA -5.5 (-115) is the lean, but go with a half-unit play at most. It's going to be tough for the Sooners to follow up their emotional win at Bama. OU has covered all 4 true road games this season, but it is just 1-3-1 ATS in 5 games in front of the home fans, so tread lightly.

Still, Missouri has tailed off, going 2-4-1 ATS in the past 7 games, including 1-1 ATS in its 2 road games this season.

Over/Under

OVER 42.5 (-115) is a good play, as Mizzou has cashed high in the past 2 outings. The Tigers are averaging 33 points per game (PPG), while allowing 32.5 PPG in those outings. The Over has a 6-4 edge on the season for Missouri, too.

While the Under cashed at Bama last week, the Sooners have cashed the Over in 2 of the past 3 games. The Over cashed in last season's meeting in Columbia, too, and it's worth noting that the Over has hit in 4 in a row in this series since Dec. 6, 2008.

For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.

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This article originally appeared on Sportsbook Wire: Missouri Tigers at Oklahoma Sooners odds, picks and predictions

Reporting by Daniel Dobish, Sportsbook Wire / Sportsbook Wire

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