There are some truly great sitcoms on TV right now, and St. Denis Medical has got to be one of the best. Despite the show being set in a hospital , it consistently elicits loud bursts of laughter, and I knew immediately I’d be tuning in every week . With such a talented cast and quick, smart jokes, I have no idea how the actors keep a straight face. So we asked them what does make them break character during filming, and they had some excellent responses.

St. Denis Medical ’s second season hit the 2025 TV schedule in early November with no sophomore slump in sight. In fact, Wendi McLendon-Covey, David Alan Grier and company delivered possibly the funniest episode yet in that double premiere. While I doubled over with laughter at Ron’s scream (then rewound it and laughed all ove

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