Fantasy football start em, sit em MNF lineups advice for Panthers vs. 49ers on Monday Night Football in Week 12 (2025). NFL matchups analysis and MNF starts/sits.

Don't look now, but the Carolina Panthers have quietly jumped out to a 6-5 record and are in NFC playoff contention. Carolina has been among the worst teams in the NFL over the last few years, but this gritty squad will get the chance to show out in primetime against the mighty San Francisco 49ers. The stakes are high, and many fantasy managers will have matchups decided in this final game of Week 12.

Below, read about the fantasy football outlooks for key players like Tetairoa McMillan , Jauan Jennings , Ricky Pearsall , Rico Dowdle , George Kittle , Brock Purdy , Bryce Young , and more. Which Panthers and 49ers

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