Happy Thanksgiving, everybody!

The NFL blessed us with a great slate of football games to bet on this Thanksgiving.

These are Deadspin's top betting picks for two of the 2025 NFL Thanksgiving games.

Packers vs. Lions

The Detroit Lions will host the Green Bay Packers in a Week 1 rematch. This game is wildly important for the NFC North. The Packers are 0.5 games ahead of the Lions, entering this game with a 7-3-1 record compared to a 7-4 record.

The biggest key to this game is the location. Detroit is going to have a massive edge at home, while Green Bay’s defense has struggled a bit on the road.

Overall, the Packers’ offense has traveled well. They’ve been better on the road, averaging 27.8 points per game. They’ve struggled defensively, though , allowing .378 points per play [compa

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