The San Francisco 49ers (8-4) and Cleveland Browns (3-8) meet Sunday for a Week 13 matchup. Kickoff from Huntington Bank Field in Cleveland, Ohio, is scheduled for 1 p.m. ET (CBS). Let's analyze BetMGM Sportsbook's NFL odds around the 49ers vs. Browns odds and make our expert NFL picks and predictions for the best bets.

The Browns lead the all-time series 13-8, including a 19-17 victory Oct. 15, 2023, in the most recent meeting in Cleveland. The home team has won the past 5 meetings since the Browns went on the road and won 13-12 in 2003.

The 49ers polished off the Carolina Panthers 20-9 as a 7.5-point favorite on Monday Night Football in Week 12, easily cashing the Under (49). QB Brock Purdy threw for 193 yards, 1 TD and 3 INTs. All 3 miscues came in the first half, bu

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