Chinese researchers have used multi-omic profiling to comprehensively map the immune landscape of sepsis, which could lead to new precision treatments.

The findings, in Nature Immunology , revealed both shared and divergent immune responses shaped by the anatomical site of infection and the patient’s age.

It also identified distinct subsets of immune cells with unique functional states and molecular profiles, which could potentially be used as biomarkers or targets for precision immunotherapy.

“Our study provides a comprehensive immune landscape of sepsis across infection sources and age groups, highlighting critical immune subsets as potential biomarkers and therapeutic targets,” reported Qian Je, PhD, from First Affiliated Hospital of Chongqing Medical University, and colleagues.

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