Not every cast member could remain on Grey’s Anatomy in season 22.

During the May 2025 finale of the hit ABC series, Piper Perabo played a mother of a patient who brought a highly flammable acetylene tank into the operating room to force Amelia (Caterina Scorsone) to perform a high-risk surgery to save her daughter. The hostage situation included interns Simone (Alexis Floyd) and Adams (Niko Terho) at risk while Meredith (Ellen Pompeo) tried to save them before it was too late.

Despite performing the operation successfully, the tank was accidentally opened, which let the flammable contents leak onto the operating floor. The final moments of the finale showed an explosion that only Meredith and Warren (Jason George) officially survived — for now.

While showrunner Meg Marinis wouldn’t con

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