Nov 30, 2025; Cleveland, Ohio, USA; San Francisco 49ers tight end George Kittle (85) reacts after catching a long pass during the second half against the Cleveland Browns at Huntington Bank Field.

The holiday season is in full swing, and the USA TODAY Sports staff is in the spirit of giving. They are back to deliver you the best NFL bets of Week 15 in one place. Last week, the team went 2-2, with Devin Neal producing and Daniel Jones tossing an interception before he suffered a season-ending Achilles injury.

The crew posted profitable picks in back-to-back weeks and is back eyeing a sweep this Sunday with the playoff hunt front and center.

The Tampa Bay Buccaneers and Atlanta Falcons kicked off the week on Thursday night, and with bye weeks behind us, there is a massive 14-game NFL schedule today.

Our staff of experts narrows down the best NFL bets for Sunday. They have provided those NFL predictions for Week 15 below, supplying an in-depth analysis on spreads, totals, player props and anytime touchdowns with odds from BetMGM. Best of luck if you tail.

Best bets NFL Week 15

All odds listed are provided by BetMGM Sportsbook. Access USA TODAY Sports Scores and Sports Betting Odds hub for a complete list.

49ers TE George Kittle anytime TD (+130)

Ayrton Ostly, NFL writer: San Francisco is back from a late bye and gets a Titans team fresh off its second win of the season at home. It's the first of three home games in four weeks to close the season for San Francisco.

Tennessee has struggled against tight ends this year, but especially over the last two weeks. After giving up three touchdowns to the position over their first 11 games, they've allowed that many in the past two weeks: one each to Brenton Strange, Harold Fannin Jr. and David Njoku.

Kittle's playing better than all three of them this year and got an extra week of rest ahead of this game. Look for him to find the end zone in this one.

Giants QB Jaxson Dart OVER 205.5 passing yards (-111)

Jacob Camenker, NFL writer: Dart has only topped 200 passing yards in three of his eight starts this season, but he should be a good bet to get past the mark this week. The Commanders have allowed the fifth-most passing yards to quarterbacks this year (3,392) and just surrendered a three-touchdown game to J.J. McCarthy.

If that wasn't enough, the Giants appear content to de-emphasize Dart as a runner in an effort to protect him ahead of his second season. He logged just four carries against the New England Patriots in Week 13 – a season-low in a start for him – so that could force the first-round rookie to operate more as a pure passer in the final month of the season.

Ravens RB Derrick Henry 2+ TDs (+380)

Tom Viera, NFL writer/editor: Over the last seven games, Henry has 692 yards and 6 TDs. The Ravens and Bengals met two weeks ago and King Henry had 104 yards and a TD even though the Ravens played from behind most of the game. Henry should see a massive workload with Justice Hill (IR) and Keaton Mitchell banged up.

Henry in December is a train you want to get on board with. Baltimore is trailing the Steelers and outside the playoffs entering Week 15, so expect them to be uber-aggressive against this very generous Cincinnati defense. Over the last two months, the Bengals' defense ranks last in rushing yards allowed, yards per rush, and rush success rate, and second-to-last in yards before contact per rush and EPA per play.

This AFC North matchup has the second-highest total on the slate (51.5), and the Ravens have an implied team total of 27 this Sunday. Henry averaged 128.5 yards over the last four games in 2024 and should start the final stretch of the 2025 season with a bang with Baltimore's playoff hopes hanging in the balance.

This article originally appeared on USA TODAY: What are NFL best bets for Week 15? We asked our experts for top predictions, player props

Reporting by Tom Viera, Ayrton Ostly and Jacob Camenker, USA TODAY / USA TODAY

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