Moffitt Cancer Center researchers have discovered that B cell lymphoma alone, without the effects of chemotherapy, radiation, or other treatments, can accelerate aging in immune cells and tissues. Their study, published in Cancer Cell , shows that young T cells are driven into an aged-like state when exposed to B cell lymphoma and these changes resemble those observed in the T cells of much older individuals leading to increased inflammation, impaired protein balance, and disrupted iron regulation.

“Cancer doesn’t just grow in isolation; it has widespread effects on patients. We found that lymphoma alone, without treatment, is enough to provoke systemic signs of aging,” said senior author John Cleveland, PhD, chief scientific officer at Moffitt. “This helps explain why many cancer p

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