A team of Australian researchers has identified a set of genes that encode the GATOR1 protein complex as instrumental in the suppression of lymphoma . The research, published in Nature Communications , used CRISPR/Cas9 to develop an in vivo screen of MYC-driven lymphoma in mouse models to show that the loss of NPRL3, DEPDC5, or NPRL2 in the GATOR1 complex significantly accelerates lymphoma development, providing new targets for developing treatments.

“This finding contributes to the expanding landscape of targetable vulnerabilities in this disease context. Our results highlight the nuanced differences in cancer dependencies that can emerge when distinct upstream alterations converge on a shared signaling pathway,” the researchers wrote.

The study was a collaboration between the O

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