Measuring acoustic emissions from microbubbles exposed to ultrasound could enable researchers to optimize opening of the blood-brain barrier (BBB), and thus treatment delivery, in patients with gliomas.

“The BBB has been a long-standing obstacle to effectively delivering many therapeutic agents into the brain,” explain Graeme Woodworth, MD (University of Maryland School of Medicine, Baltimore) and co-authors in Device . “Microbubble-enhanced transcranial focused ultrasound (MB-FUS) has emerged as a novel paradigm for overcoming this by enabling temporary, iterative, safe, and localized opening.”

MB-FUS is a noninvasive technique that combines FUS with microbubbles to open the BBB. The tiny (1–10 µm), gas-filled bubbles are injected into the bloodstream and then vibrate and oscillate

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