When is Joe Mixon coming back? Will Joe Mixon play again this season? Read about Joe Mixon's return date and injury updates for 2025.

Houston Texans running back Joe Mixon (ankle) has officially been placed on the Non-Football Injury (NFI) list. This designation means he will miss at least the first four games of the 2025 NFL season, creating immediate headaches for fantasy football managers.

Mixon was expected to anchor Houston’s backfield once again after posting strong numbers in 2024. Instead, his absence opens the door for uncertainty, both in the Texans’ offense and in fantasy draft rooms.

The key questions now are when Mixon might return, how effective he’ll be when he does, and whether he’s worth targeting in drafts. Let’s break it down. Be sure to check all of our fantasy f

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