A new multi-center study led by researchers from the Center for Infection and Immunity (CII) at Columbia University Mailman School of Public Health shows that people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) have heightened and dysregulated immune responses to microbial stimuli which result in systemic inflammation, impaired metabolism, and the potential to develop molecular subtypes of the disease. The research, published in npj Metabolic Health and Disease , provides a new, more detailed map of the immune and metabolic changes wrought by ME/CFS and suggest the potential for new treatments for this and other post-infection syndromes such as post-treatment Lyme disease.

“Our findings indicate that people with ME/CFS have dysregulated immune responses to common

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