The Week 2 college football schedule may lack the top-10 matchups that last Saturday saw, but it will see two of the winningest programs in the history of the sport colliding. No. 15 Michigan will head to Norman, Okla., to face the 18th-ranked Sooners, with OU 5.5-point favorites per the latest Week 2 college football lines. The two schools rank in the top five, all-time, in college football championships amongst major programs while each is also in the top six in wins. Elsewhere, there are several matchups which feature in-state battles as bragging rights will be on the line.

Iowa vs. Iowa State has been contested since 1894, and the latest installment of the series sees the No. 16 Cyclones as 3.5-point favorites, according to the Week 2 college football odds. There is also No. 3 LSU

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