Week 1 of the 2025 NFL regular season continues on Friday in São Paulo, Brazil with a matchup between the Kansas City Chiefs (-3) and Los Angeles Chargers. The opening weekend also features heavyweight matchups like the Lions vs. Packers (-2) and 49ers vs. Seahawks (+2.5), plus Vikings vs. Bears (+1.5) on Monday night. Meanwhile, the game with the slimmest Week 1 NFL spread is Dolphins vs. Colts (-1), while Broncos vs. Titans (-8.5) is the largest spread remaining on the Week 1 NFL odds board.

Who should you back in each of the games on the remaining Week 1 NFL schedule, and how should you handle all your NFL money line, NFL over/under and NFL against the spread spread picks? Before making any Week 1 NFL picks or Week 1 NFL score predictions, you need to see the NFL against the spread, N

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