University of Michigan researchers have used single-cell RNA sequencing, single-cell multiomics, and spatial transcriptomics to produce a detailed cellular map of the mouse prostate that has revealed potential therapeutic targets for castration-resistant prostate cancer.

“This is the first time anyone has used these three tools to get an integrated view of prostate cancer treatment response and resistance,” said senior author Sethu Pitchiaya, PhD, assistant professor of urology and a member of Rogel Cancer Center at the University of Michigan.“By comparing our results to publicly available human sequencing data, we were able to draw parallels to the human prostate and disease.”

Co-author Arul Chinnaiyan, MD, PhD, Hicks Professor of Pathology and Urology and investigator at the Howard Hug

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