Complete NFL Week 1 betting lines, point spreads, and betting odds analysis. Expert predictions on the best spreads to bet and Las Vegas totals for Sunday's games.

The NFL is back, baby, and my fellow bettors, do we have an incredible lineup of content planned out for you this season!

This article is intended to be a first look at every NFL game in Week 1, providing the spreads, totals, odds, and analysis that you need to start your research for your Week 1 NFL wagers.

Check back later in the week for our writers' favorite bets, props, and picks. But for now, here is a breakdown of every NFL game with some trends and data for your consideration! Be sure to check all of our fantasy football rankings for 2025:

2025 fantasy football rankings

Running back (RB) fantasy football rankings

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