The NFL regular season begins with the 2025 NFL Kickoff Game between the Philadelphia Eagles and Dallas Cowboys on Thursday night. Philadelphia is the defending Super Bowl champion and swept the season series between these rivals with a pair of blowout wins last year. Dallas missed the playoffs after making an appearance the previous three seasons, but quarterback Dak Prescott is returning from a season-ending injury. Kickoff is set for 8:20 p.m. ET on Thursday at Lincoln Financial Field. According to the latest NFL odds, Philadelphia is favored by 8.5 points, while the over/under for total points scored is 48. The Eagles are -437 money line favorites, while the Cowboys are +337 underdogs.

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