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Amanda Knox thinks her infamous murder case over in Italy is all one big joke ... at least if you listen to her new standup routine.

Foxy Knoxy poked fun at her Italian nightmare during a recent gig at the Tacoma Comedy Club in Washington ... joking that motherhood is a lot harder than being locked up in an Italian jail.

As you know ... Amanda was a Seattle college student studying abroad in 2007 when she and her Italian boyfriend of a week were thrown behind bars for the rape and murder of her British roommate, Meredith Kercher . Getty

Amanda was ultimately acquitted -- as was her then-BF Raffaele Sollecito -- after spending 4 years in prison.

In her standup routine, Amanda points out she also spent 4 years producing the Hulu show "The Twisted Tale of Ama

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