Mike's Week 2 college football betting picks against the spread for Saturday, September 6, 2025. Free CFB betting predictions, odds analysis & ATS picks from RotoBaller.

It was a fun time in Week 1. We let the NFL have Thursday this week, which means a huge Saturday for real football. There are 79 games on Saturday, but only 48 of those are FBS vs. FBS games.

Most of the games between FCS and FBS schools aren't even on the major sportsbooks. Some sites will create a line for you if you ask, but it most certainly won't favor you. Since those are off the books anyway, I won't pick them, either. I have to draw the line somewhere.

We won't complain about those things. There are a lot of great matchups in Week 2, even if it lacks the star power of Week 1! We'll take a look at Week 2 of the 2

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