The Seattle Seahawks open the 2025 season at home against NFC West rivals, the San Francisco 49ers , on Sunday. Seattle finished 10-7 and just missed the playoffs in coach Mike Macdonald's first season, while the 49ers were a disappointing 6-11 a year after making a Super Bowl appearance. Sunday's game marks a potential return to action for San Francisco's star running back, Christian McCaffrey, while quarterback Sam Darnold makes his regular season debut for Seattle. The 49ers have won six of the last seven meetings, but fell most recently in a 20-17 final at home last November.

Kickoff from Lumen Field in Seattle is set for 4:05 p.m. ET. San Francisco is a 1.5-point favorite in the latest 49ers vs. Seahawks odds from SportsLine consensus, while the over/under for total points scored

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