A proposed rollout of a world-first chlamydia vaccine for koalas could cost "squillions and squillions", wildlife advocates warn.

University of the Sunshine Coast researchers have spent more than a decade developing the breakthrough, single-use vaccine which they hope to launch in 2026.

The Australian Koala Foundation has queried the vaccine rollout's likely effectiveness.

Foundation chair Deborah Tabart claimed any suggestion that governments fund vaccinations for wild koalas "can only be mocked", saying the task would be effectively impossible.

"It would cost squillions and squillions," she told AAP.

It might be impossible to vaccinate enough koalas in wild populations to ensure a sufficient level of immunity, Ms Tabart said.

"It was almost impossible to vaccinate almost all humans

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