The San Francisco 49ers have been arguably the most unlucky team in the NFL since the beginning of last season. After a year full of injuries in 2024, the 2025 season has started off the same way.

George Kittle went down last week with a hamstring injury. He will miss at least the next four games due to that injury. Unfortunately, he wasn't the only key player lost for the 49ers.

Star quarterback Brock Purdy is dealing with toe and shoulder injuries. He has already been ruled out for Week 2 and there have been some reports that he could miss up to five weeks. That would be a true worst-case scenario for San Francisco to kick off the season.

49ers Emerge as Possible Fit for Major QB Trade After Brock Purdy Injury

Ahead of the 49ers' Week 2 matchup against the New Orleans Saints, which

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