Tampa Bay Buccaneers running back Bucky Irving (7) celebrates with quarterback Baker Mayfield (6) after scoring a touchdown against the Atlanta Falcons during the third quarter at Mercedes-Benz Stadium in Atlanta, Georgia.

The Tampa Bay Buccaneers (1-0) visit the Houston Texans (0-1) on Monday Night Football in Week 2. Kickoff from NRG Stadium is at 7 p.m. ET (ABC / ESPN). Let's analyze BetMGM Sportsbook's NFL odds around the Buccaneers vs. Texans odds and make our expert NFL picks and predictions for the best bets.

The Buccaneers opened the season with a 23-20 road win over the NFC South rival Atlanta Falcons Sept. 7 as 1-point favorites. The Under (47.5) cashed. QB Baker Mayfield threw 3 TD passes, including the game-winner to rookie WR Emeka Egbuka with 59 seconds left. It was Egbuka’s second TD catch in his NFL debut. The Falcons missed a potential game-tying 44-yard field goal in the final seconds.

The Texans opened the season with a 14-9 road loss to the LA Rams Sept. 7 as 3-point underdogs. The Under (43.5) cashed. QB C.J. Stroud threw an interception and was sacked 3 times as the offense was limited to 265 yards and kept out of the end zone. The Texans went 2-for-9 on third down.

The Texans lead the all-time series with the Bucs 5-1, winning each of the last 5 meetings. Their last meeting was a 39-37 win Texans home win Nov. 5, 2023.

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Buccaneers at Texans odds

Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 8:08 a.m. ET.

  • Moneyline (ML): Buccaneers +125 (bet $100 to win $125) | Texans -150 (bet $150 to win $100)
  • Against the spread (ATS): Buccaneers +2.5 (-105) | Texans -2.5 (-115)
  • Over/Under (O/U): 42.5 (O: -110 | U: -110)

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Buccaneers at Texans key injuries

Buccaneers

  • WR Chris Godwin (foot) out
  • OL Luke Goedeke (foot) questionable
  • OL Tristan Wirfs (knee) out

Texans

  • OL Jake Andrews (ankle) out
  • WR Tank Dell (knee) out
  • WR Christian Kirk (hamstring) out

Buccaneers at Texans picks and predictions

Prediction

Texans 27, Buccaneers 24

Moneyline

Mayfield, after a career season with 41 TD passes, started 2025 with 3 TD tosses.

Can he keep it up against the Texans? Rams QB Matthew Stafford had 245 passing yards and a TD in Week 1, but the Texans only scored 9 points against the Rams defense, which has allowed fewer than 20 points in 5 of their last 6 regular-season games dating back to 2024.

The Bucs allowed 358 total yards to the Falcons, and QB Michael Penix Jr. had 298 passing yards and a TD.

Houston will find more offensive rhythm against the Bucs in a higher-scoring game.

But with only a 2.5-point spread, you will get better value betting Texans to cover.

PASS.

Against the spread

The Buccaneers were 5-3 ATS on the road last season. Of the Texans’ 11 wins between the regular season and playoffs, 10 were by at least 3 points.

BET TEXANS -2.5 (-115).

Over/Under

Their last meeting was a barnburner in 2023 with 76 total points.

The Buccaneers’ season opener had 43 points, and each of their final 5 games last season, including the playoffs, had 43 or more.

BET OVER 42.5 (-110).

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This article originally appeared on Sportsbook Wire: Tampa Bay Buccaneers at Houston Texans odds, picks and predictions

Reporting by Jess Root, Sportsbook Wire / Sportsbook Wire

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